For decades, Ketamine has been used “off-label” to treat chronic pain, depression and PTSD. Recent studies * have demonstrated Ketamine’s ability to rapidly and completely reverse suicidal depression in treatment-refractory patients. No other treatment modality has demonstrated such a rapid and profound response since electroconvulsive therapy (ECT). In fact, Thomas Insel, former Director, National Institute of Mental Health (NIMH) stated that “Recent data suggest that ketamine, given intravenously, might be the most important breakthrough in antidepressant treatment in decades.” However, unlike ECT, treatment with Ketamine infusions do not require an inpatient hospital stay, and the side effect profile is more favorable then ECT which can cause memory loss. Many severely depressed patients improve significantly in a matter of hours post treatment, however, multiple rounds of infusions are usually required for a sustained response. Current research is focusing on the use of Ketamine as a treatment for those suffering with chronic pain, addiction, PTSD, and other psychiatric disorders. Our doctors remain on the front lines of the technological advancements and research regarding both the utilization of Ketamine and the effective interactions with other medications such as Botox and CGRP inhibitors for significantly improved responses. Ketamine is a good alternative to patients who are medically addicted to painkillers and want to get off of them but need effective treatment for their chronic pain condition.